Samantha "Sam" Newly is a corporate executive and hit-and-run victim who awakens after being in a coma for eight days, only to find she has amnesia. With no memories of the past, she must rediscover everything about her life and herself by looking for clues from her past.
Samantha Newly awakens in the hospital, surrounded by family and friends, but has no idea who they are or who she is.
Samantha discovers what she does for a living, and tries to diverge from her old workaholic lifestyle.
Sam assumes her role as a bridesmaid at a friend's wedding, but upon arriving, learns that the friend does not want her there.
Realizing that she has no memory of sex, Samantha considers re-experiencing her first time or waiting for the right guy.
Sam runs into an ex-boyfriend and discovers that he has a restraining order against her. Sam tries to win her father's love and affection.
Sam makes an appointment with a hypnotherapist to recover her lost memories, but her revelations lead Sam to believe that Regina and Howard may not be her real parents.
Regina decides it's time for Samantha to begin dating again and sets Sam up on an unannounced blind date with a contractor. Meanwhile, Andrea plans a trip to Rome with her latest fling.
Guilt overwhelms Samantha when she covers up an accident with her father's car so well that he pities her and buys Sam a new vehicle.
After falling hard for Kevin and feeling that she may be in love with him, Samantha begins to move too fast in the relationship, which may scare Kevin into breaking up with her. Meanwhile, Sam begins to redirect her feelings for Kevin onto Todd.
Samantha is forced to move back into the apartment when she discovers that she could be evicted for subletting it to Todd, who has invited his new girlfriend, Chloe, to move in with him.
Samantha is stunned when Winston Funk, the wealthy co-owner of the real estate firm, asks her to marry him, especially since Sam knows that Andrea is completely smitten by him.
Sam tries to persuade her boss to shut down a construction project that would destroy an endangered butterfly habitat.
Sam asks a complete stranger to Todd's photo gallery exhibit to make it look like she has moved on, but she soon discovers the man may have crossed her path in the past.
Samantha is convinced that Regina is having an affair with someone, while Andrea considers opening a coffee shop with Dena.
Samantha decides to put her relationship with Todd on hold until he breaks up with Chloe as he promised. Elsewhere, Regina and Andrea disagree on how to plan Samantha's birthday party.
Samantha teams up with her mother for a dance competition in order to beat Regina's nemesis, Paula Drake. But Paula hires a ringer who may help her claim victory.
In an attempt to find new direction in her life, Samantha suddenly decides to go to Africa and volunteer to help those in need.
Sam is given pills as part of a clinical trial to regain some of her lost memories. As memories come flooding in, she is reminded of how bad she used to be.
Desperate for cash and in need of a job, Samantha reluctantly agrees to team up with Regina and start a real estate business.
After an altercation with a cop, Samantha is arrested and given community service, where she meets Natalie, a troubled young woman.
After finally telling current boyfriend Owen that she lives with ex-boyfriend Todd, Sam discovers that Owen's best friend is also his ex-girlfriend, Willow.
Sam's decision to invite Owen for dinner to meet her parents turns into a disaster when his philosophy about chicken farms rubs Howard the wrong way.
Samantha struggles with trying to be the environmentalist in order to impress philanthropist boyfriend Owen.
After getting her heart broken, Sam goes on a family vacation - with Andrea and Dena in tow - and discovers an old flame from her forgotten youth.
When Todd discovers something peculiar about Andrea's pro basketball-playing date, Sam decides to meddle in the guy's affairs in order to keep her friend from being hurt.
Feeling her biological clock ticking and desiring a baby, Sam borrows Dena's dog in an attempt to find out if she's nurturing enough to care for something other than herself.
After a series of misunderstandings, Sam discovers that she needs to be a better friend to Frank, while Andrea's boyfriend is outed as gay.
Sam loses big at the craps table in Vegas. But a chance meeting with her ex-boss, billionaire Winston Funk, could be the answer to her financial dilemma.
When Sam starts dating a rock superstar, she becomes so embarrassed by Andrea and Dena's fan-like reactions that she begins to alienate them.
To atone for sins of the past, Sam tries to ensure that Todd gets a job by sabotaging his competition. Regina puts Dena's house on the market, unbeknownst to Dena.
Sam learns that, because of a family feud between Regina and her sister, she's been kept in the dark about having an aunt and a grandmother.
After being hired by Winston Funk to head his charity foundation, Samantha hires Andrea as her Vice President of Legal Affairs. But Sam soon regrets hiring her best friend when Andrea's all-consuming obsession with planning her wedding becomes top priority over her job.
Sam's attempt to plan a new first date with Todd continues getting pre-empted when her boss, Winston, keeps throwing work at her in a effort to rekindle their past romance.
Sam tries to be cordial to Winston Funk's ex-wife Gigi, who played an important role in her life before the accident.
On Andrea's wedding day, Sam finds herself at a crossroads and must choose between being with Winston Funk or Todd. Meanwhile, Regina and Howard discover their lives are beginning to take separate paths.
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