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Floriane "Flo" Bohringer has been the host of a feminist morning show for 10 years and is happily in a relationship with her colleague Milan. She has little time for her private life. Her 15-year-old daughter Luna, whose problems she knows little about, commutes between her apartment and that of her ex-husband Jens, one floor above her. Her older son Carlo and Kathi, her ex-husband's new partner, also live there. Flo is committed to a women's shelter, for which she is trying to secure support from a Berlin senator. When Flo comes home one evening, Luna is lying lifeless on her bed. She committed suicide out of lovesickness. Desperate Flo receives a tip from a stranger about the company "Plan B," which enables time travel. She decides to travel back a few days to prevent Luna's death.

Flo wonders whether, despite her career as a busy talk show host, she can still adequately support her daughter Luna. She cautiously tries to do some things differently than in her "first life," which has consequences that surprise her. For example, she receives the blows from Luna's boyfriend Pasqual, which were previously intended for her daughter. At Luna's request, she withdraws the complaint she filed and even invites Pasqual to dinner. She also tries to improve the relationship between Luna and her brother Carlo. But Luna still experiences periods of depression.

When Luna is admitted to a clinic with severe depression, Flo Bohringer embarks on a second journey back in time, one that goes back about six months further than the first. Flo had previously discovered that Luna's loss at a gymnastics competition was the trigger for her becoming estranged from her gymnast friends. So Flo tries to get Luna excited about joining a theater group where the competitive spirit is less present. When Flo wins an award for her radio show, she takes her two children and her ex-husband with her to Hamburg. While she is exchanging intimate details with her ex-husband, the two children go out. However, Carlo loses sight of Luna and calls his parents for help. Flo finds her daughter in a darkroom having violent intimacy with a stranger. Luna collapses when confronted by her accusations.

Flo's ex-husband and his wife take Luna on a trip to Italy, where she initially feels very comfortable. But when she falls unhappily in love, she becomes depressed again. After her return, she has to go to a clinic. Previously, on her radio show, Flo accused a Berlin senator of wanting to cut funding for women's protection, even though this hadn't been made public yet. Using her knowledge from the future, she publicly exposes him as a liar. She is fired as a result, and a colleague takes over the show. Although Flo's relationship with her colleague is going very well and her son Carlo has found a nice girlfriend, Flo decides to take a third trip back in time, this time 10 years to the day Luna started school. Unlike the first time, she takes the time and accompanies Luna to the classroom for her first lesson. When Luna comes to her parents' bedroom a little later because of a bad dream, she doesn't take her back to her childhood bedroom like the first time, but lets her continue sleeping in her parents' bed. When she is asked to host the new radio show, she refuses.

Flo now approaches her life fundamentally differently. After Luna starts school, she accompanies her to the classroom for the next few days until her daughter tells her that this is no longer necessary. When Luna receives a children's kitchen stove from Flo's mother, Flo criticizes it but accepts it. At the same time, Flo encourages her mother to spend more time with her family. Flo accompanies her son to training and tells her husband how much she needs and loves him. A chance encounter with her potential lover from her "first life" gets her nowhere. She succeeds in dissuading Luna from hitting her friends and helping her gain more self-confidence. When Flo's mother has a heart attack, she doesn't look for a nursing home for her, but cares for her at home. To achieve this, she even gives up her job at a women's shelter. When her grandmother dies, Flo comforts her screaming daughter. And when her husband is accused of sexually harassing a student, she stands by him. After all, she knows that the accusation is unjustified, which actually turns out to be true in this life as well.

Flo gets a coughing fit and goes to her doctor for a check-up. It turns out that she is suffering from a form of blood cancer. This is the result of Pfeiffer's glandular fever, which she once contracted from her children. In her previous lives, this infection did not occur because she was on a business trip and could not care for her children herself. Luna tells her that, despite chemotherapy, she will die in a few months before her paid "Plan B" is over. Because this time, Luna has paid for a "Plan B." In her previous life, in which her mother died, she became a successful chef in a Michelin-starred restaurant. Now she has traveled back in time to persuade her mother and her doctor to undergo a stem cell transplant, which is currently still undergoing experimental testing. Unfortunately, it turns out that neither her stem cells nor her brother's are suitable for this. Flo accepts her inevitable death because it has finally been proven that she could indeed save Luna from depression and suicide. At the last moment, a stem cell donor is found, but whether the therapy will actually save her life remains open.