As a U.S. Deputy Marshal based in Miami, Florida's Gold Coast, Karen Sisco must deal with the underbelly of South Beach nightlife and Palm Beach high life while tracking down fugitives. She also struggles to win the respect of her fellow officers. Karen occasionally gets advice from her father, a retired Miami police officer turned private investigator, who is Karen's confidant, counselor, and confessor.
Karen, who has hazy memories of a motel shoot-out that left her injured, is attracted to a charter-boat owner (Patrick Dempsey) who may be wanted by the FBI.
Trying to catch two escaped cons who stole a $3 million Babe Ruth-autographed baseball from a mob boss (Danny DeVito), Karen enlists help from their mother .
While in pursuit of a charming con man (Thomas Kretschmann), Karen is surprised by the reappearance of a former mob accountant (Xander Berkeley) who had been relocated.
Karen must protect an annoying counterfeiter (Jim True-Frost) who says he remembers her from high school (she doesn't remember him at all). Meanwhile, a robber (John Diehl) picks up right where he left off hours after being released from prison.
Karen's efforts to apprehend a prison escapee (Tim Guinee) interferes with romancing a Florida Marlins pitcher.
Six months after he knocked her out, Karen pursues a murderer who's back in Miami. Elsewhere, Marshall is asked to check up on a cheating husband.
Karen and her father (Carla Gugino, Robert Forster) becomes hostages in a bank robbery.
Karen takes temporary custody of a smart-aleck murder witness, a wily preteen girl whose incarcerated father seeks an early parole to dodge a death threat and collect a stash of stolen money.
Karen goes undercover to investigate the overdose-related death of her father's pal, an down-on-his-luck ex-con Marshall suspects was murdered because of his gambling debts.
Complete episode guide for Karen Sisco with detailed information about every season and episode including air dates, summaries, ratings, and streaming availability in United States.
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